DNA

Humans have been altering animals and plants through selective breeding for millennia; but, because these changes typically reduce the capacity for survival and reproduction in the wild, they do not spread to wild populations. Alterations accomplished using CRISPR, which enables scientists to edit a cell’s DNA with unprecedented precision, are different in one crucial respect: The process can result in “gene drive,” a naturally occurring feature of some genes that enables them to spread through a population over generations, even if they do not help survival (and thus reproduction).

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Simply put, we can now contemplate altering wild populations in very specific and consequential ways. Those changes can be highly positive. By altering certain features of mosquitos, we could reduce or even eradicate ancient scourges such as malaria and dengue that afflict hundreds of millions of people each year. (Malaria alone kills a child every 90 seconds, on average.) By permanently immunizing the relevant animal populations, we could prevent new cases of Lyme and other diseases that originate in wild organisms, or we could block newly emergent pathogens such as the Zika virus, which has been linked to an epidemic of stunted brain development in newborns in Latin America.

As for the environment, human activities have already impacted every ecosystem on Earth, with far-reaching consequences – for us and many other species – many of which are yet to unfold. Gene drive elements could potentially reverse much of this damage. For example, limiting invasive species – such as cane toads in Australia, mosquitoes in Hawaii, or rats and mice almost everywhere – could help to restore damaged biomes. And eliminating pests’ attraction to our crops, without diminishing their capacity to fulfill their other ecological roles, would remove the need for toxic pesticides.

As we attempt to realize these tremendous potential benefits, however, we must bear in mind that the effects of gene drive interventions will be shared by entire communities. Given the vast complexity of ecosystems, careful research will be needed to assess the consequences of each intervention before proceeding.

CRISPR gene drives also highlight a problem that goes beyond ecology: Existing systems for developing and evaluating new technologies are woefully inadequate for powerful new tools with broad impacts. It should be self-evident that technologies like gene drives, which don’t require widespread adoption to have a widespread effect, should never be released without informed community consent. Yet history shows the opposite pattern, with decision-making seldom factoring in environmental consequences or citizens’ opinions.

Nowadays, there are few opportunities for public input until after products are developed, when it is typically too late to make changes. By ignoring potentially helpful contributions from an increasingly knowledgeable public, closed-door technological development has precluded balanced assessments and created acrimony – a dangerously irresponsible and wasteful outcome for both science and society.

CRISPR gene drives offer an opportunity to chart a new course. For starters, public notification and broadly inclusive discussions should always precede and inform development of gene drive interventions in the lab. A clear description of the potential impact of an experiment – as my colleagues and I have providedfor the technology as a whole – must be followed by transparency throughout the development process. This community-guided approach to research provides opportunities to identify and address potential problems and concerns during development. If a perceived problem cannot be adequately addressed, researchers should be prepared to terminate the project.

Transparency and collective scrutiny would also help to ensure that scientists fulfill their fundamental responsibility to protect against laboratory accidents. Experiments involving gene drive organisms are almost unique in terms of the potential harm that a mishap could cause beyond the lab. Though DNA-level changes spread by one gene drive can be overwritten by another gene drive – an important safeguard against unwanted side effects and misuse – the ecological impacts would not be so easy to reverse.

To be sure, most gene drive experiments will pose little, if any, environmental risk. Nonetheless, an accidental release would prove devastating to public confidence in researchers’ ability to develop this powerful technology with wisdom and humility. That is why my colleagues and I have detailed, demonstrated, andpublicized several easily implementable confinement strategies.

Another feature of a responsible approach would be a commitment by scientists to evaluate each proposed gene drive intervention – say, immunizing mice so that they cannot transmit Lyme disease to ticks – individually, rather than making a blanket decision on the technology as a whole. After all, the benefits and risks of each intervention would be entirely different.

A final safeguard against the irresponsible development of gene drive technology is to ensure that early interventions are developed exclusively by governments and nonprofit organizations. Given the potential of financial incentives to skew the design and results of safety tests, keeping the profit motive out of the development and decision-making processes will encourage balanced assessments.

The bottom line is that existing models for technological development are inadequate for technologies with broadly shared effects. Only with early discussion, transparent research, careful safeguards, and community guidance can we build a responsive model of scientific development well suited to ecological technologies. Given the life-saving (and environment-saving) potential of CRISPR gene drive interventions, let us determine how to develop them – and when to decline to do so – together.

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Jakob_EGO

Jorn Jakob Albert Boor. (36) Ik heb mijn leven lang menselijke interactie, tegenstellingen en tegenstrijdigheden geobserveerd en hieruit een conclusie getrokken. Theorie, ervaring en ondersteuning vanuit de vele verscheidene vriendschappen en gebeurtenissen hebben het mogelijk gemaakt tot de kern van het menselijk bestaan en evolutie van het bewustzijn op individueel en collectieve zingeving en progressie. De verschillende specialisaties, hierarchische levels van behoeften (egoisme) en non verbale en verbale intentie's en communicatie eigenschappen (egocentrisch) zijn een fundamentele doelstelling en persoonlijke ontwikkeling die ik graag wil delen en ten dienste wil stellen zodat het de creatie en evolutie van ons natuurlijke zijnsvorm transcends in het geestelijke/spirituele zijnsvorm in ons aller belang en zoals het gedetaileerd in allerlei verscheidene historische takken van sport is benoemd en vastgelegd op feiten en profetisch onderbouwde geschriften. wijsheden en legacies. Defragmentatie van deze inzet, inzichten, kennis en opofferingen ten behoeve van ons aller belang en bestaansrecht. Via het informeren en verzamelen van kennis verwacht ik de chaos en verbroken connectie's weer samen te brengen en hiermee de macht over vrede, begrip, diversiteit en samenwerkings verbanden naar een resonerende en gebalanceerde bestaansrechtelijke fundering terug te brengen en mijzelf en mijn service van toegevoegde waarde te laten zijn. Vanuit mijn eigen ervarings deskundigheid en relatieve overzichten op globaal niveau. Creativiteit. Spontaniteit en Probleemoplossende eigenschappen en de bij behorende communicatieve vaardigheden zouden het varkentje moeten wassen. UNESCO onderschrijft een groot deel van de conclusie en bestaansrecht van deze theorie/evolutie model en symboliek voortgebracht via de grootheden en culturen en eerder bestaansvormen uit het verleden. Dit is de finishing touch en de start van een nieuw begin met rust. vrede en creatieve ontwikkelingen en rechtvaardige basis berustende op eenwording en ware identiteit van de mensheid. De overwinning welke onze wederzijdse verantwoordelijkheid in alle facetten van het bestaan vrijheid en zijn bevierd zal worden! # Het zal geschieden. # Mijn thuis is waar liefde zegeviert # Huis van Jakob / Rechtvaardigheid # Jakob 's Ladder / Vigilant. .. http://jornboor.blogspot.nl https://jakobinfo.wordpress.com @Jakob_EGO "Oil To The Fire Submitted In Respect For The Sacred Dance On Infinity. "

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